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Stability - Accelerated Aging Reference Chart

Accelerated Aging is a technique used to rapidly simulate an extended time at room temperature. The technique is commonly used in studies designed to determine expiration dating for sterile medical devices. While 55oC is most commonly used as the accelerated temperature, many other elevated temperature are also used and may be desirable depending on product composition and packaging. Two values are required to determine the real time aging equivalency for a storage period at an elevated temperature.

The values are:

  1. The temperature used for accelerated aging, and
  2. The temperature assigned as ambient.

Different temperatures may be assigned as ambient depending on the anticipated storage of the product.

Aging to Ambient Temperature Equivalencies (Aging Factor = 2)

Aging Temp.   
Ambient Temp.   



Days in Year

Formula



Aging
Factor   
Days to Age 1 Year at Ambient   
Weeks to Age 1 Year at Ambient
      40
23° 365

÷

21.7 112.3 16
45 23° 365

÷

22.2 79.5 11.4
50 20° 365

÷

23.0 45.6 6.5
  23°  

÷

22.7 56.1 8.0
  25°  

÷

22.5 64.5 9.2
55 20° 365

÷

23.5 32.3 4.6
  23°  

÷

23.2 39.7 5.7
  25°  

÷

23.0 45.6 6.5
60 20° 365

÷

24.0 22.8 3.3
  23°  

÷

23.7 28.0 4.0
  25°  

÷

23.5 32.3 4.6
65 20° 365

÷

24.5 16.1 2.3
  23°  

÷

24.2 19.8 2.8
  25°  

÷

24.0 22.8 3.3
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